Proceedings of the International scientific and practical conference ―American Ukrainian Forum of Science and Education‖ (April 13-15, 2026) / Publisher website: www.naukainfo.com. – New York, USA, 2026. - 235 p.

183 utilization, impaired energy metabolism and dysfunction of key signaling pathways responsible for synaptic plasticity and cognitive processes. The research showed that insulin resistance is associated with cognitive decline, memory impairment and structural changes in the cerebral cortex. It also contributes to neurodegenerative processes through neuroinflammation, oxidative stress and accumulation of pathological proteins (β-amyloid and tau protein) linking it to the risk of Alzheimer’s disease and dementia. Thus, insulin resistance is one of the key mechanisms linking metabolic disorders with cognitive decline and neurodegeneration. REFERENCES: 1. Stephanie Kullmann; Dominik Blum; Benjamin Assad Jaghutriz; Christoph Gassenmaier; Benjamin Bender; Hans-Ulrich Häring; Gerald Reischl; Hubert Preissl; Christian la Fougère; Andreas Fritsche; Matthias Reimold; Martin Heni. Central insulin modulates dopamine signaling in the human striatum. J Clin Endocrinol Metab, 2021, 106(10):2949–2961. DOI: https://doi.org/10.1210/clinem/dgab410 2. Chaojuan Huang; Yuyang Zhang; Mingxu Li; Qiuju Gong; Siqi Yu; Zhiwei Li; Mengmeng Ren; Xia Zhou; Xiaoqun Zhu; Zhongwu Sun. Genetically predicted brain cortical structure mediates the causality between insulin resistance and cognitive impairment. Sec. Clinical Diabetes, Volume 15, 2024. DOI: https://doi.org/10.3389/fendo.2024.1443301 3. Hamish A. Deery; Emma Liang; Robert Di Paolo; Katharina Voigt; Gerard Murray; M. Navyaan Siddiqui; Gary F. Egan; Chris Moran & Sharna D. Jamadar. Peripheral insulin resistance attenuates cerebral glucose metabolism and impairs working memory in healthy adults. npj Metabolic Health and Disease, 2024, 2:17. DOI: https://doi.org/10.1038/s44324-024-00019-0 4. Martin Heni. The insulin resistant brain: impact on wholebody metabolism and body fat distribution. Diabetologia, 2024, 67:1181–1191. DOI: https://doi.org/10.1007/s00125-024-06104-9