Proceedings of the International scientific and practical conference ―Science at the Frontier of Progress‖ (June 8-10, 2026) / Publisher website: www.naukainfo.com. – Paris, France, 2026. - 178 p.

22 growth factors. Through this activation, it orchestrates important biological processes such as cell proliferation, differentiation, survival, and apoptosis (Table 1), thereby maintaining immune homeostasis and ensuring effective responses to pathogenic threats [6]. Table 1. Canonical cytokine–JAK–STAT interactions and their physiological impact [6]. Functional classification Cytokine JAK STAT Biologicaleffect Regulation of the immune response IL2 JAK1 JAK3 STAT5 Proliferation and differentiation of T and B lymphocytes IL4 JAK1 JAK3 STAT6 Differentiation of CD4 T cells into Th2, activation of B lymphocytes IL10 JAK1 TYK2 STAT3 Inhibition of pro-inflammatory cytokine production ІЛ-19 JAK1 TYK2 STAT3 Anti-inflammatory role, enhancement of Th2 response ІЛ-20 JAK1 TYK2 STAT3 Regulation of keratinocyte proliferation, skin inflammation IL21 JAK1 JAK3 STAT3 Modulation of B, T and NK cell responses Inflammatory Response IL6 JAK1 JAK2 TYK2 STAT1 STAT3 Induction of acute phase proteins, lymphocyte activation IL-12 JAK2 TYK2 STAT4 Induction of Th1 differentiation, IFN-γ production IL17 JAK1 JAK2 STAT3 Induction of pro-inflammatory cytokine production IL23 JAK2 TYK2 STAT3 Differentiation of CD4 T cells into Th17 ІЛ-24 JAK1 TYK2 STAT3 Antitumor activity, apoptosis induction Іл-26 JAK1 TYK2 STAT1 STAT3 Pro-inflammatory effects on epithelial cells IFN-γ JAK1 JAK2 STAT1 Macrophage activation, increased MHC expression ІЛ-13 JAK1 STAT6 Mucus production, airway remodeling, and allergic inflammation Antivira lResponse IFN-α, IFN- β JAK1 TYK2 STAT1 STAT2 Induction of antiviral genes, inhibition of virus replication Development And Maturationof ImmuneCells IL-3 JAK2 STAT5 Promoting the survival and differentiation of hematopoietic progenitors ІЛ-7 JAK1 JAK3 STAT5 Survival and proliferation of B and T cell precursors IL-9 JAK1 JAK3 STAT5 Stimulation of mast cell proliferation IL-15 JAK1 JAK3 STAT5 Maturation and survival of NK cells Tissue Protection ІЛ-11 JAK1 JAK2 TYK2 STAT3 Stimulation of platelet production