Proceedings of the International scientific and practical conference ―Cambridge Science and Education Conference‖ (May 15-17, 2026) / Publisher website: www.naukainfo.com. - Cambridge, United Kingdom, 2026. - 429 p.

115 respectively, compared with rats with low LOC. This may indicate greater functional activity of the cells. In addition, in animals with high LOC, a significantly larger number of binuclear hepatocytes by 44% and a binuclear / mononuclear hepatocyte ratio by 46% were found, which may indicate more intensive intracellular regeneration processes. Also, in these rats, a significantly larger distance between the nuclei of adjacent hepatocytes by 31% was found, which is most likely due to larger cell sizes. The number of nucleoli in the nuclei of hepatocytes of rats with different LOC did not differ significantly (Table 1). Table 1. Histomorphometric parameters of the liver (M ± m, n = 15) Indicators Low level of O 2 consumption, 1700 ml/kg/h High level of O 2 consumption, 2150 ml/kg/h Hepatocyte diameter, μm 16.0±0.48 16.9±0.56 Area, μm 2 hepatocyte nucleus cytoplasm Nuclear-cytoplasmic ratio 231.7±6.09 33.5±1.85 198.2±4.55 0.17±0.007 275.9±7.2* 34.6±2.43 241.3±15.04* 0.14±0.004* Number of hepatocytes, pcs. / 23000 μm 2 total mononuclear binuclear Ratio binuclear / mononuclear hepatocytes 67.1±2.43 65.5±2.32 1.6±0.35 0.024±0.005 67.8±3.54 65.5±3.06 2.3±0.58* 0.035±0.007* Number of nucleoli in the nucleus of a hepatocyte, pcs. 1.87±0.07 1.67±0.08 Distance between the nuclei of adjacent hepatocytes, μm 7.18±0.14 9.38±0.35* Relative parenchyma area, % 92.1±0.41 94.1±0.47 *P<0.05 – significant of differences compared to rats with low oxygen consumption Also, in rats with different LOC, differences were found in the state of connective tissue in the liver. Thus, in the liver of rats with high LOC, a smaller