Proceedings of the International scientific and practical conference ―Cambridge Science and Education Conference‖ (May 15-17, 2026) / Publisher website: www.naukainfo.com. - Cambridge, United Kingdom, 2026. - 429 p.

116 amount of connective tissue was noted. This is evidenced by a 25% smaller relative area of connective tissue, a 28% smaller Vizotto coefficient (ratio of relative area of connective tissue to area of sinusoid) and a 15% smaller number of connective tissue cells and their ratio to the number of hepatocytes compared to rats with low LOC (Fig. 1). The smaller the amount of connective tissue in the liver, the greater its functional activity, better intercellular interaction, etc. Fig. 1. Histomorphometric indicators of the connective tissue state in the liver: A – relative area of the sinusoid network, B – Vizotto coefficient, C – number of connective tissue cells (pcs/1000 μm 2 ), D – ratio of the number of connective tissue cells to the total number of hepatocytes. I – rats with low oxygen consumption, II – rats with high oxygen consumption. *P<0.05 – significant of differences compared to rats with low oxygen consumption. Further studies are needed to fully understand the mechanisms of the relationship between the level of oxygen consumption and the state of the liver parenchyma, which we plan to do in the future. The results obtained are interesting for practical medicine in developing new effective methods for the prevention and treatment of liver pathology in patients depending on their LOC. Conclusions Rats with different levels of oxygen consumption have differences in the structure of the liver. In rats with a high level of oxygen consumption histomorphometric signs of greater functional and regenerative activity of the liver