Proceedings of the International scientific and practical conference ―New York Global Science Conference 2026‖ (May 18-20, 2026) / Publisher website: www.naukainfo.com. – New York, USA, 2026. - 322 p.

255 Metabolic and nutritional causes: diabetes, malnutrition and vitamin deficiency, uremia; Toxic causes: alcohol, metals, drugs (for example platinum derivatives, bortezomib, vincristine, paclitaxel, thalidomide, linezolid, metronidazole, zalcitabine, stavudine); Immune-mediated disorders: Guillain-Barré syndrome, chronic inflammatory demyelinating neuropathy (CIDP), multifocal acquired demyelinating sensory and motor neuropathy (Lewis-Sumner syndrome), systemic vasculitides (for example, polyarteritis nodosa and granulomatosis with polyangiitis), isolated peripheral nervous system vasculitis, neuropathies in systemic connective tissue diseases (Sjögren’s syndrome, systemic lupus erythematosus), sarcoidosis, coeliac disease, inflammatory bowel diseases; Infections: HIV, leprosy, herpes zoster, borreliosis (Lyme disease), hepatitis C; Dysglobulinemias: primary systemic amyloidosis, cryoglobulinemia, macroglobulinemia, myeloma; Neoplasia-related causes: direct infiltration of malignancy, sensory neuronopathy. Painful polyneuropathy significantly impairs the patient's quality of life. Therefore, it is important to know the pathogenetic causes of the development of this subtype of neuropathy in order to shape the trajectory of examination and treatment. REFERENCES: 1. Gierthmühlen J, Attal N, Baskozos G, et al. What is associated with painful polyneuropathy? A cross-sectional analysis of symptoms and signs in patients with painful and painless polyneuropathy. Pain . 2024;165(12):2888-2899. doi:10.1097/j.pain.0000000000003310 2. Jacoby N, Anziska Y. A Practical Approach to Diagnosing Peripheral Neuropathies. Semin Neurol. 2025 Feb;45(1):4-12. doi: 10.1055/s-0044- 1791721. Epub 2024 Oct 21. PMID: 39433285.