Proceedings of the International scientific and practical conference ―New York Global Science Conference 2026‖ (May 18-20, 2026) / Publisher website: www.naukainfo.com. – New York, USA, 2026. - 322 p.

254 can be classified into 3 groups of neuropathic pain profiles: sensory loss, thermal hyperalgesia, and mechanical hyperalgesia [1]. The development of neuropathic pain is primarily associated with damage to small fibers. Small-fiber neuropathy is a subtype of sensory neuropathies, which exclusively or predominately affects small diameter fibers (Aδ) and unmyelinated (C) fibers. However, signs and symptoms of polyneuropathy are not restricted to sensory dysfunction but may also include motor and autonomic disturbances. Although some characteristic symptoms may be indicative of certain etiologies of polyneuropathy especially genetic causes, the clinical phenotype usually varies between patients even with the same etiology. There is likely a bidirectional relationship between the initiation and maintenance of pain and factors such as genetic variants, sociodemographic factors, physical activity, multiple psychosocial, and lifestyle factors, including sleep problems, life satisfaction, and adverse childhood events, as well as pain-related worrying and emotional functioning (anxiety or depression) [1;2]. Diabetes mellitus is the most common cause of painful polyneuropathy.is the most common cause of painful polyneuropathy. It has been estimated that diabetes affects 8.5 % of people in Europe and diabetic sensorimotor polyneuropathy occurs in 10-54 % of patients with either type 1 or type 2 diabetes. A third of patients with diabetic sensorimotor polyneuropathy suffer from neuropathic pain. For the majority of patients over 50 years of age, no specific cause for a painful polyneuropathy can be identified. Neuropathic pain has been estimated to be present in 65-80 % of idiopathic polyneuropathies [2,3]. There are several pathogenetic groups of diseases that are the causes of painful polyneuropathies [2;4]: Inherited diseases: hereditary sensory (and autonomic) neuropathy (particularly type 1), familial amyloid polyneuropathy (transthyretin-related, TTR-FAP), Fabry disease, Tangier disease, porphyria;